Tesamorelin Peptide Overview

Tesamorelin is a synthetic polypeptide composed of 44 amino acids, analogous to growth hormone-releasing hormone (GHRH). It features modifications at the N-terminus designed to improve stability and resistance to enzymatic deactivation compared to natural GHRH.

Mechanism of Action

Research suggests Tesamorelin acts on GHRH receptors in the anterior pituitary gland, potentially increasing the production and secretion of growth hormone (hGH). This, in turn, stimulates the synthesis of insulin-like growth factor-1 (IGF-1). Studies indicate it may lead to a:

• 69% increase in overall growth hormone levels.
• 55% increase in mean growth hormone pulse area.
• 122% surge in IGF-1 levels.

Chemical Makeup

• Molecular Formula: C221H366N72O67S
• Molecular Weight: 5136 g/mol
• Other Known Titles: (3E)-hex-3-enoylsomatoliberin

Research and Clinical Studies

• Lipodystrophy & Visceral Fat: In Phase III studies, subjects showed a significant decrease (at least 15.4%) in visceral adipose tissue. Other research suggests it may lead to a reduction of up to 25% in visceral fat.
• Fat Fractions (NAFLD): A 12-month study reported that 35% of subjects exhibited a reduction in hepatic fat fraction (HFF) by more than 5%.
• Muscle Tissue: Computed tomography (CT) scans suggested potential improvements in the density and overall volume of muscle tissues, particularly in the rectus abdominis and psoas major.
• Cognition: Clinical trials have investigated its effect on neurocognitive performance in aging immunodeficient models with mild cognitive impairment.
• Insulin Sensitivity: Studies involving Type II diabetes subjects reported no significant changes in fasting glucose or glycosylated hemoglobin levels.

Note: This product is sold by Republic One Labs for research and laboratory purposes only and is not intended for human consumption.