CJC-1295 Peptide (No DAC) Overview

CJC-1295 WITHOUT DAC, also known as Modified GRF (1-29), is a synthetic 29-amino acid derivative of the naturally occurring Growth Hormone-Releasing Hormone (GHRH). It contains four substituted amino groups designed to prevent enzymatic degradation and extend its half-life, though it lacks the Drug Affinity Complex (DAC) found in other versions.

Mechanism of Action

• Pituitary Interaction: It targets GHRH receptors on pituitary cells, potentially triggering signaling pathways (like cAMP or IP3) that stimulate the synthesis and release of growth hormone (GH).
• Pulsatility: Unlike the DAC version which provides a steady release, the “No DAC” version is thought to mimic more natural pulsatile GH release.
• Synergy: It is often researched in combination with Growth Hormone Secretagogues (GHSs) like Ipamorelin to potentially achieve greater GH elevation through synergistic effects.

Research and Potential Applications

• GH-IGF-1 Axis: Studies have suggested it may cause a significant rise in GH and a ~28% increase in IGF-1 levels.
• Body Composition: Research in models has noted potential for increased muscle tissue hypertrophy and skin tissue thickness.
• Heart & GI Health: Preliminary murine models suggest potential for improving heart rate and cardiac tissue repair post-injury. It may also interact with receptors in the gastrointestinal system to influence bowel movement.

Chemical Makeup

• Molecular Formula: C152H252N44O42
• Molecular Weight: 3367.9 g/mol
• Key Modifications: Includes substitutions at the 2nd (D-alanine), 8th (Glutamine), 15th (Alanine), and 27th (Leucine) positions to bolster resistance against molecular degradation.

Note: This product is sold By Republic One Labs for research and laboratory purposes only and is not intended for human consumption.