Ipamorelin Peptide Overview

Ipamorelin is a synthetic pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2) classified as a Growth Hormone Secretagogue (GHS). It is designed to bind to ghrelin receptors (GHS-R) on the pituitary gland, potentially stimulating the release of growth hormone (hGH) without significantly affecting other hormones like prolactin or ACTH.

Chemical Makeup

• Molecular Formula: C38H49N9O5
• Molecular Weight: 711.86 g/mol
• Other Known Titles: NNC 26-0161

Research and Clinical Studies

• Selective Agonism: Research in murine and swine models suggests Ipamorelin is highly selective for GH release, similar to GHRH.
• Growth Hormone Synthesis: In vitro studies suggest it triggers cellular signaling (PLC, IP3, and DAG pathways), leading to the exocytosis of growth hormone vesicles. One clinical trial reported over a 60-fold increase in GH levels compared to a placebo.
• Bone Tissue: Studies in murine models using DEXA scans suggest the peptide may increase bone mineral content (BMC) and body mass by stimulating osteoblasts.
• Digestion: Research indicates Ipamorelin may accelerate gastric emptying and enhance the contractility of stomach smooth muscles, potentially mitigating decelerated peristalsis.
• Appetite and Weight: By interacting with ghrelin receptors, it may enhance hunger signals. Studies noted a surge in body weight and potentially elevated serum leptin levels in research models.
• Nitrogen Balance: Investigations suggest Ipamorelin may exert anabolic actions by improving nitrogen balance and reducing urea-N synthesis (CUNS) in catabolic states.

Note: This product is sold by Republic One Labs for research and laboratory purposes only and is not intended for human consumption.