KPV Peptide Overview

KPV is a tripeptide composed of the amino acids Lysine, Proline, and Valine. It is a C-terminal fragment of the alpha-melanocyte-stimulating hormone (α-MSH) protein. Research suggests it may possess significant anti-inflammatory properties by inactivating inflammatory pathways and inhibiting the release of pro-inflammatory cytokines.

Chemical Makeup

• Molecular Formula: C16H30N4O4
• Molecular Weight: 342.43 g/mol
• Other Known Titles: MSH (11-13), ACTH(11-13), alpha-MSH(11-13)

Research and Clinical Studies

• Intestinal Protection: Studies on murine models suggest that KPV may reduce inflammatory cells and anti-enzymatic symptoms in cases of bowel dysfunction. It may be transported to the site of inflammation via the PepT1 transporter.
• Ulcerative Colitis: Research indicates KPV might protect mucosal surfaces and downregulate TNF-α, a key marker of inflammation, potentially accelerating mucosal healing in colonic cells.
• Wound Healing: In corneal tissue research, KPV was observed to accelerate re-epithelialization and stimulate cell viability. These effects may be linked to nitric oxide (NO) activity.
• Scar Formation: Murine models showed that KPV exposure led to improved skin healing and a smaller scar area compared to control groups, potentially due to reduced levels of leukocytes and mast cells.
• Antipyretic Potential: An early study on rabbits suggested that the peptide could act on the nervous system to reduce body temperature to optimal levels.
• Dermatitis: Comparative studies with α-MSH suggest KPV may be effective in reducing swelling related to skin rashes and dermatitis.

Note: This product is sold by Republic One Labs for research and laboratory purposes only and is not intended for human consumption.