NAD+ Peptide Overview

Nicotinamide Adenine Dinucleotide (NAD+) is an endogenous nucleotide that regulates primary functions such as metabolism, energy production, and DNA repair. It acts as a secondary messenger and is synthesized naturally via the de novo mechanism from the amino acid tryptophan. Research suggests it exerts over 500 enzymatic reactions and acts as a coenzyme in redox functions.

Mechanism of Action

NAD+ is a coenzyme for three major classes of enzymes:

• Sirtuins (SIRTs): May stimulate mitochondrial homeostasis, stem cell regeneration, and nerve protection.
• Poly ADP ribose polymerases (PARPs): Synthesize polymers that lead to genome stability.
• Cyclic ADP ribose synthetases (cADPRS): Key immunological cells (CD38 and CD157) that may stimulate stem cell regeneration and DNA repair.

Chemical Makeup

• Molecular Formula: C21H27N7O14P2
• Molecular Weight: 663.43 g/mol
• Other Known Titles: nicotinamide adenine dinucleotide

Research and Clinical Studies

• Productive Aging: Studies in mice suggest that NAD+ intermediates (NMN and NR) may reduce weight gain, increase energy metabolism, and improve lipid profiles.
• Neurodegenerative Activity: Research on aged mice models suggests mitochondrial functions can be restored in nerve and brain cells when exposed to NAD+ intermediates.
• DNA Repair: Studies indicate that replenishing NAD+ can significantly improve DNA base excision repair activity and cell viability after ischemic stress (oxygen/glucose deprivation).
• Organ Health (Liver & Kidney): Experimental models suggest NAD+ may help prevent obesity and alcoholic hepatitis while protecting against glucose-induced kidney cell hypertrophy.
• Skeletal & Cardiac Function: Research indicates NAD+ plays a vital role in cellular respiration (glycolysis and the citric acid cycle). In cardiac studies, it reportedly produced cardioprotective functions against ischemic injury in mice.

Note: This product is sold by Republic One Labsfor research and laboratory purposes only and is not intended for human consumption.