Summary Report, YPB.229, Semax (10mg), 12-22-25Semax Peptide Overview

Semax is a synthetic peptide analog of the adrenocorticotropic hormone fragment 4-7 (ACTH 4-7). It is modified with a Pro-Gly-Pro (PGP) sequence at its C-terminal end to potentially enhance its ability to cross the blood-brain barrier and increase its stability against enzymatic breakdown. Unlike the full ACTH hormone, this fragment is reported to have specific actions within the brain rather than systemic hormonal effects.

Mechanism of Action

• Enkephalin Regulation: Research suggests it may inhibit enzymes that degrade enkephalins (neurotransmitters involved in pain perception and stress response).
• Neurotransmitter Modulation: It has been observed to potentially increase the secretion of dopamine and elevate levels of brain-derived neurotrophic factor (BDNF).
• Immune & Vascular Impact: Some studies speculate it may alter gene expressions related to the immune and vascular systems.

Chemical Makeup

• Molecular Formula: C39H54N10O10S
• Molecular Weight: 854.99 g/mol
• Other Known Titles: ACTH (4-7)PGP, HY-P1146

Research and Clinical Studies

• Nootropic Action: In murine models, Semax was linked to a significant elevation of 5-HIAA (a serotonin metabolite), suggesting enhanced serotonergic activity and improved cognitive function.
• Anxiety & Stress: Research involving neonatal models suggested that Semax could mitigate anxiety-like behaviors induced by SSRIs or maternal deprivation, potentially by restoring monoamine levels in the brain.
• Vascular Protection: Studies on heart models indicated that Semax might protect against vascular damage and cardiac hypertrophy following myocardial infarction.
• Neuroprotection: A clinical trial of 100 subjects with ischemic stroke reported improved restoration of damaged neurological functions following Semax exposure, as analyzed by EEG mapping.
• Memory & Focus: Small-scale trials under high-stress conditions suggested that Semax might increase memory recall and focus intervals within 24 hours of use.

Note: This product is sold by Republic One Labsfor research and laboratory purposes only and is not intended for human consumption.